Blog Post Image: Scientists reveal structural secrets of enzyme used to make popular anti-cholesterol drug

Directed evolution of the LovD enzyme yields a variant with 29 mutations that does not require a carrier protein to produce the anti-cholesterol drug simvastatin. As observed by microsecond molecular dynamics simulations, the mutated enzyme LovD9 spends more time in an active configuration that allows the simvastatin-producing reaction to proceed. Image credit: UCLA/Codexis (Click image to enlarge)

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